Two people have died, another remains critical and three other passengers suffered minor injuries following a horror single vehicle car accident yesterday afternoon south west of Cooktown.

Police said a station wagon carrying six people was travelling north bound on the Mulligan Highway at Lakeland, near Boggy Creek Bridge around 3.38pm before it suddenly left the road and rolled a number of times.

Police heartbreakingly confirmed the driver of the station wagon, and one passenger died at the scene, while another passenger was flown to Cairns in a critical condition.

The remaining three passengers were transported to Cooktown Hospital with minor injuries.

The Forensic crash unit continues to investigate the terrible accident.

Update: Confirmed by QAS

- A woman in her 40s was located deceased at the scene.

- A male in his 20s was located deceased at the scene.

- A male in his 40s was flown to Cairns hospital with signifigant pelvis, chest and head injuries in a critical condition.

- A male in his 20s was transported to Cooktown hospital in a stable condition with back injuries.

- A female in her 20s was transported to Cooktown hospital with back injuries.

- A female patient sustained minor injuries and did not require further treatment or transport.